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DOCTOR – Static

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More than 3,000 GPs and specialists have already ordered over 17,000 myDNA pharmacogenomic tests to enable more informed, personalized prescribing for their patients

References Clinical FAQs

DOCTOR – Pharmacogenomic

Hear from our Associate Professor Les Sheffield

DOCTOR – About the myDNA test

About our test

The myDNA Medication test is a pharmacogenomic test where DNA analysis identifies variations in a number of genes that influence medication response.

A comprehensive report is written by the myDNA clinical team and includes an interpretation of the patient’s genetic results, any prescribing considerations for current medications, as well as information on other medications covered by the myDNA test so that this can be referred to for the future.

Currently, myDNA Medication reports particularly concentrate on the genes encoding metabolising enzymes (i.e. CYP450 enzymes) which are found mainly in the liver as well as the gut wall. These genetic variations predict the level of enzyme activity which in turn results in increased or decreased plasma concentrations and drug exposure.

For many medications increased plasma concentrations, due to reduced enzyme activity, can lead to adverse effects. Reduced plasma concentrations, due to increased enzyme activity, can lead to poor therapeutic response.

Enzyme function can also be affected by factors other than genotype, including age, the effect of co-administered drugs (i.e. drug-drug interactions), and the presence of liver disease. These should be taken into account when considering the myDNA Medication Reports.

Reports must be delivered by a suitable healthcare professional. myDNA provides training for medical staff to assist in the understanding of these reports. If you would like to know more about this training, please email us: clinical@mydna.life.

Our myDNA healthcare professional clinical support line is also available on 1300 436 373 9am-5pm (AEST) business days to provide information on the test, including details of which medications are currently covered and provide clinical guidance on test results.

References Clinical FAQs Medications covered

DOCTOR – Who is it Recommended For

The patients likely to benefit from myDNA testing include those who are:

The patients likely to benefit from myDNA testing include those who are:

  • Experiencing side effects to specific medications
  • Not responding to specific medications
  • Requiring doses of specific medications outside the recommended range
  • Planning to start on a new medication covered by the myDNA test
  • Taking multiple medications initiated by different prescribers

Each person who takes a myDNA test will receive a highly customized medication report and ongoing access to their Explore myDNA – a secure online portal that provides information relevant to the person’s genetic profile.

DOCTOR – Evidence

EVIDENCE BEHIND myDNA

In our reports, myDNA references the guidelines of the Royal Dutch Pharmacists Association – Pharmacogenetics Pharmacogenomics Working Group and the Clinical Pharmacogenetics Implementation Consortium (CPIC). Generally, the emphasis is on CPIC guidelines, given their more recent publication.

The following published guidelines contain evidence for gene-drug associations for which dosage adjustments have been recommended. These can be accessed online at Pharmgkb.

  1. CPIC Guideline for CYP2D6 and CYP2C19 genotypes and dosing of Tricyclic Antidepressants
  2. CPIC Guideline for CYP2D6 and CYP2C19 genotypes and dosing of Selective Serotonin Reuptake Inhibitors (SSRIs)
  3. Dutch Pharmacogenetics Working Group guidelines which include a number of antidepressant and antipsychotic medications

DOCTOR – How to Order

How to order

The myDNA test kits can be purchased directly by patients from their nearest myDNA Accredited Pharmacy. The sample is then sent to the lab for analysis and a personalized report is sent back to the requesting Doctor and pharmacy. Reports start at just $149 for a single condition report and $199 for the multiple condition report.

Find Accredited Pharmacy