myDNA Pharmacogenomic testing
More than 3,000 GPs and specialists have already received over 12,000 myDNA pharmacogenomic tests to enable more informed, personalised prescribing for their patients.
Analysis of around 4,750 test results found that 70% of people have a finding that predicts a significantly altered drug metabolism for one or more medications.
Video: Associate Professor Les Sheffield, Clinical Geneticist, shares more about personalised medicine.
About the myDNA Medication test
The myDNA Medication test is a pharmacogenomic test which identifies variations in a number of genes that affect medication response.
Currently, myDNA Medication testing concentrates on the genes encoding the metabolising enzymes (i.e. CYP450 enzymes) which are found mainly in the liver as well as the gut wall. These genetic variations predict the level of enzyme activity which in turn results in increased or decreased plasma concentrations and drug exposure.
Increased plasma concentrations, due to reduced enzyme activity, can lead to adverse effects. Reduced plasma concentrations, due to increased enzyme activity, can lead to poor therapeutic response.
Enzyme function can also be affected by factors other than genotype, including age, the effect of co-administered drugs (i.e. drug-drug interactions), and the presence of liver disease. These should be taken into account when considering the myDNA Medication test result.
Who is the myDNA Medication test recommended for?
The patients likely to benefit from myDNA Medication testing include those who are:
- Experiencing side effects to specific medications
- Not responding to specific medications
- Requiring doses of specific medications outside the recommended range
- Planning to start on a new medication covered by the myDNA Medication test
- Taking multiple medications initiated by different prescribers
Each person who takes a myDNA Medication test will receive a personalised medication report and ongoing access to myDNA Explore – a secure online portal that provides information relevant to the person’s genetic profile.
How to order myDNA
Patients can be referred to a myDNA accredited pharmacy for a cheek swab test starting at $199. The sample is then sent to the lab for analysis and a personalised report is sent back to the requesting doctor and to the myDNA accredited pharmacist.