{"id":130278,"date":"2024-03-05T14:14:20","date_gmt":"2024-03-05T22:14:20","guid":{"rendered":"https:\/\/www.mydna.life\/en-us\/?page_id=130278"},"modified":"2025-01-16T15:05:58","modified_gmt":"2025-01-16T23:05:58","slug":"whole-exome-sequencing","status":"publish","type":"page","link":"https:\/\/www.mydna.life\/en-us\/whole-exome-sequencing\/","title":{"rendered":"Whole Exome Sequencing"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row css=&#8221;.vc_custom_1702945561061{padding-top: 10vh !important;}&#8221;][vc_column width=&#8221;1\/6&#8243;][vc_column_text]Turnaround Time<\/p>\n<p><strong>21-25 business days<\/strong>[\/vc_column_text][\/vc_column][vc_column width=&#8221;1\/6&#8243;][vc_column_text]Price<\/p>\n<p><strong>Inquire for pricing<\/strong>[\/vc_column_text][\/vc_column][vc_column width=&#8221;1\/6&#8243;][vc_column_text]Testing completed by<\/p>\n<p><strong>Gene by Gene<\/strong>[\/vc_column_text][\/vc_column][vc_column width=&#8221;1\/6&#8243;][\/vc_column][vc_column width=&#8221;1\/6&#8243;][\/vc_column][vc_column width=&#8221;1\/6&#8243;][\/vc_column][\/vc_row][vc_row css=&#8221;.vc_custom_1702945023379{padding-top: 5vh !important;padding-bottom: 1vh !important;}&#8221;][vc_column width=&#8221;1\/2&#8243;][vc_tta_tabs active_section=&#8221;1&#8243;][vc_tta_section title=&#8221;Requirements&#8221; tab_id=&#8221;1702944281951-8a02fdf3-644c&#8221;][vc_column_text css_animation=&#8221;fadeIn&#8221; css=&#8221;.vc_custom_1709594135260{padding-top: 20px !important;padding-bottom: 20px !important;}&#8221;]<\/p>\n<div style=\"margin-left: 15px;\">\n<h6><strong style=\"color: var(--primary);\">| <\/strong><strong>Sample Requirements<\/strong><\/h6>\n<p>myDNA will provide buccal (cheek) swab kits with each order.<\/p>\n<p>Each test requires one buccal swab which are included in each kit. This is the preferred sample collection method.<\/p>\n<p>myDNA will provide return packaging and a pre-paid shipping label.<br \/>\n<sup>*Shipping fees will apply.<\/sup><\/p>\n<p>If necessary, myDNA can accept most DNA sample types, including:<\/p>\n<ul role=\"list\">\n<li>Extracted DNA: 20ul of 50ng\/ul, OD260\/OD280 ~ 1.8, include details of extraction method with samples<\/li>\n<li>Blood: 3-5cc drawn in EDTA (purple-top) tube<\/li>\n<\/ul>\n<\/div>\n<p>[\/vc_column_text][\/vc_tta_section][vc_tta_section title=&#8221;Shipping&#8221; tab_id=&#8221;1702944281962-5cbcf3d8-52f3&#8243;][vc_column_text css_animation=&#8221;fadeIn&#8221; css=&#8221;.vc_custom_1702944838130{padding-top: 20px !important;padding-bottom: 20px !important;}&#8221;]<\/p>\n<div style=\"margin-left: 15px;\">\n<h6><strong style=\"color: var(--primary);\">| <\/strong><strong>Shipping<\/strong><\/h6>\n<ul role=\"list\">\n<li>For blood samples, please ship at room temperature in an insulated container. IT\u2019S IMPORTANT TO NOTE:\u00a0<strong>DO NOT HEAT OR FREEZE SAMPLE<\/strong><\/li>\n<li>For buccal swab please follow shipping information provided<\/li>\n<\/ul>\n<\/div>\n<p>[\/vc_column_text][\/vc_tta_section][vc_tta_section title=&#8221;Methodology&#8221; tab_id=&#8221;1702944285434-782f6740-ca7a&#8221;][vc_column_text css_animation=&#8221;fadeIn&#8221; css=&#8221;.vc_custom_1702948302348{padding-top: 20px !important;padding-bottom: 20px !important;}&#8221;]<\/p>\n<div style=\"margin-left: 15px;\">\n<h6><strong style=\"color: var(--primary);\">| <\/strong><strong>Testing Methodology<\/strong><\/h6>\n<p>We use Twist Bioscience\u2019s Exome 2.0 for for exome capture, specific details for the panel can be found here:\u00a0<a href=\"https:\/\/www.twistbioscience.com\/products\/ngs\/fixed-panels\/exome2\">https:\/\/www.twistbioscience.com\/products\/ngs\/fixed-panels\/exome2<\/a><\/p>\n<ul role=\"list\">\n<li><strong>Platform:\u00a0<\/strong>Illumina NovaSeq 6000<\/li>\n<li><strong>Results Delivery:\u00a0<\/strong>Results are delivered via a Secure Data Transfer service which can be provided by a client, providing complete control over data retention policies. Alternatively, myDNA can support clients to set up a Secure Data Transfer<\/li>\n<\/ul>\n<\/div>\n<p>[\/vc_column_text][\/vc_tta_section][\/vc_tta_tabs][\/vc_column][vc_column width=&#8221;1\/2&#8243;][vc_column_text css_animation=&#8221;fadeIn&#8221;]<\/p>\n<div style=\"margin-left: 25px;\">\n<h3 style=\"text-align: left;\">About <span style=\"color: var(--primary);\">Whole Exome<\/span> Clinical Reporting<\/h3>\n<p style=\"text-align: left;\">Exome reporting can be a beneficial tool towards identifying undiagnosed disease that may be of genetic origin. It can also support the identification of certain disease risks. The myDNA report makes interpreting results easy so that clinicians can deliver meaningful results quicker. The report can be a first-tier test or used if other previous tests, such as traditional blood tests, have failed to identify the cause of disease.<\/p>\n<\/div>\n<p>[\/vc_column_text][vc_column_text css_animation=&#8221;fadeIn&#8221; css=&#8221;.vc_custom_1709594179825{padding-top: 2em !important;}&#8221;]<\/p>\n<div style=\"margin-left: 25px;\">\n<h3 style=\"text-align: left;\">Tests <span style=\"color: var(--primary);\">We Provide<\/span><\/h3>\n<p><strong>Whole Exome Sequencing<\/strong><\/p>\n<p><strong>Cardiovascular Panel<\/strong><\/p>\n<ul>\n<li><strong>Cardiovascular<\/strong> (174 Genes)<\/li>\n<li><strong>Congenital Heart Defect<\/strong>\u00a0(127 Genes)<\/li>\n<li><strong>Cardiomyopathy<\/strong>\u00a0(106 Genes)<\/li>\n<li><strong>Aortopathy &amp; Connective Tissue Disorders<\/strong>\u00a0(56 Genes)<\/li>\n<li><strong>Arrhythmia <\/strong>(40 Genes)<\/li>\n<li><strong>Familial Hypercholesterolemia<\/strong>\u00a0(6 Genes)<\/li>\n<\/ul>\n<p><strong>Oncology Panel<\/strong><\/p>\n<ul>\n<li><strong>Hereditary Cancer <\/strong>(113 Genes)<\/li>\n<\/ul>\n<p><strong>Other Panels<\/strong><\/p>\n<ul role=\"list\">\n<li><strong>Renal-Kidney <\/strong>(176 Genes)<\/li>\n<li><strong>Immunodeficiency (Interpretation only)<\/strong>\u00a0(50 Genes)<\/li>\n<li><strong>Parkinson Alzheimer Dementia<\/strong>\u00a0(47 Genes)<\/li>\n<li><strong>RASopathies <\/strong>(26 Genes)<\/li>\n<li><strong>Proactive Genetic Health Screen<\/strong> (311 Genes)<\/li>\n<\/ul>\n<p>Custom reports are also available upon request. Enquire with our sales team for more information.<\/p>\n<\/div>\n<p>[\/vc_column_text][vc_column_text css_animation=&#8221;fadeIn&#8221; css=&#8221;.vc_custom_1702946409776{padding-top: 2em !important;}&#8221;]<\/p>\n<div style=\"margin-left: 25px;\">\n<h3 style=\"text-align: left;\">Benefits of <span style=\"color: var(--primary);\">Whole Exome<\/span> Clinical Reports:<\/h3>\n<ul role=\"list\">\n<li>Next Generation Sequencing (NGS) technology has become an invaluable method to support diagnosis of rare genetic conditions as well as to optimize an individual\u2019s course of treatment for illness<\/li>\n<li>The exome is only ~1-2% of the genome but approximately 85% of disease-causing mutations are contained in the exome (coding regions of the genome)<sup>1<\/sup><\/li>\n<li>Whole Exome Sequencing (WES) allows for the identification of variants in coding region of genes<\/li>\n<li>Types of variants include SNVs and some copy number variants (CNVs)<\/li>\n<\/ul>\n<\/div>\n<p>[\/vc_column_text][vc_column_text css_animation=&#8221;fadeIn&#8221; css=&#8221;.vc_custom_1702946447148{padding-top: 2em !important;}&#8221;]<\/p>\n<div style=\"margin-left: 25px;\">\n<h3>Limitations of <span style=\"color: var(--primary);\">Whole Exome<\/span> Clinical Reports:<\/h3>\n<ul role=\"list\">\n<li>The report may not cover all portions of a gene, or certain genes due to sequence characteristics or presence of closely related pseudogenes<\/li>\n<li>Some deletions or duplications, or changes from repetitive sequences may not be accurately identified by this methodology<\/li>\n<\/ul>\n<\/div>\n<p>[\/vc_column_text][\/vc_column][\/vc_row][vc_row css=&#8221;.vc_custom_1702946507802{padding-top: 10vh !important;padding-bottom: 12vh !important;background-color: #fcfcfc !important;}&#8221;][vc_column width=&#8221;1\/2&#8243;][vc_column_text css_animation=&#8221;fadeIn&#8221;]<\/p>\n<h3 style=\"text-align: left;\">Inquire about <span style=\"color: var(--primary);\">Whole Exome Clinical Testing &amp; Reporting <\/span>Services Online<\/h3>\n<p style=\"text-align: left;\">Submit the adjacent Test Request Form and our laboratory will be in touch to confirm your inquiry.<\/p>\n<p>[\/vc_column_text][\/vc_column][vc_column width=&#8221;1\/2&#8243; el_id=&#8221;enquire&#8221;][vc_column_text css_animation=&#8221;fadeIn&#8221;]<\/p>\n<p style=\"text-align: center;\"><!-- HTML Forms v1.6.2 - https:\/\/wordpress.org\/plugins\/html-forms\/ -->\n<form method=\"post\"  class=\"hf-form hf-form-130774 \" data-id=\"130774\" data-title=\"Inquire about Whole Exome Sequencing\" data-slug=\"inquire-about-whole-exome-sequencing-2\" data-message-success=\"Thank you! Our team will be in touch soon.\" data-message-invalid-email=\"Please enter a valid email address.\" data-message-required-field-missing=\"Please fill in all the required fields.\" data-message-error=\"Oh no! Looks like an error occurred. Please try again, or contact our team at &lt;a href=&quot;info@genebygene.com&quot;&gt;info@genebygene.com&lt;\/a&gt;\" data-message-recaptcha-failed=\"reCAPTCHA verification failed. Please try again.\" data-message-recaptcha-low-score=\"Your submission appears to be spam. Please try again.\"><input type=\"hidden\" name=\"_hf_form_id\" value=\"130774\" \/><div style=\"display: none;\"><input type=\"text\" name=\"_hf_h130774\" value=\"\" \/><\/div><div class=\"hf-fields-wrap\"><div class=\"formfield\">\r\n  <input type=\"text\" name=\"firstname\" id=\"firstname\" required\/> \r\n  <label for=\"firstname\">First Name<\/label> \r\n<\/div>\r\n<div class=\"formfield\">\r\n  <input type=\"text\" name=\"lastname\" id=\"lastname\" required\/> \r\n  <label for=\"lastname\">Last Name<\/label>\r\n<\/div>\r\n<div class=\"formfield\">\r\n  <input type=\"email\" name=\"Email\" id=\"EMAIL\" required\/>\r\n  <label for=\"EMAIL\">Email<\/label>\t\t\t\t\t\t\t\r\n<\/div>\r\n<div class=\"formfield\">\t\t\t\t\t\t\t\r\n  <input type=\"tel\" name=\"Phone\" id=\"PHONE\" required\/>\r\n  <label for=\"PHONE\">Phone<\/label>\r\n<\/div>\r\n<div class=\"formfield\">\r\n  <input type=\"text\" name=\"clinicname\" id=\"clinicname\" required\/>\r\n  <label for=\"clinicname\">Company\/Clinic\/Provider, etc.<\/label>\t\t\t\t\t\t\r\n<\/div>\r\n<div class=\"formfield\">\r\n  <input type=\"text\" name=\"samples\" id=\"samples\" required\/>\r\n  <label for=\"samples\">Number of Samples<\/label>\t\t\t\t\t\t\r\n<\/div>\r\n<div class=\"formfield\">\r\n  <textarea name=\"Details\" id=\"inquiry-details\" placeholder=\"Leave your inquiry details below\"><\/textarea>\r\n  <label for=\"inquiry-details\">Please leave inquiry details:<\/label>\t\t\t\t\t\t\t\r\n<\/div>\r\n<div class=\"formfield\">\r\n\t<input type=\"submit\" value=\"SUBMIT\" \/>\r\n<\/div>\r\n\r\n<script>\r\n  var emailfield = document.getElementById('partner-sign-up-EMAIL');\r\n\r\n  emailfield.addEventListener('input', function(){\r\n    if(emailfield.value !== \"\"){\r\n      emailfield.classList = 'hasvalue';\r\n    }else{\r\n      emailfield.classList = '';\r\n    }\r\n  });\r\n<\/script><noscript>Please enable JavaScript for this form to work.<\/noscript><\/div><\/form><!-- \/ HTML Forms --><\/p>\n<p>[\/vc_column_text][\/vc_column][\/vc_row][vc_row css=&#8221;.vc_custom_1702946507802{padding-top: 10vh !important;padding-bottom: 12vh !important;background-color: #fcfcfc !important;}&#8221;][vc_column width=&#8221;1\/2&#8243;][\/vc_column][vc_column width=&#8221;1\/2&#8243;][vc_column_text css_animation=&#8221;fadeIn&#8221;]<\/p>\n<p style=\"text-align: center;\"><span class=\"text-span-3\"><strong style=\"color: var(--primary);\">Note:\u00a0<\/strong><\/span>For individuals interested in these services, please speak to your healthcare professional.<\/p>\n<p>[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column width=&#8221;1\/2&#8243;][vc_column_text]<\/p>\n<h5 style=\"color: var(--primary);\">References<\/h5>\n<ol role=\"list\" start=\"\">\n<li>Majewski, J., Schwartzentruber, J., Lalonde, E., Montpetit, A. &amp; Jabado, N. What can exome sequencing do for you?\u00a0<em>J. Med. Genet.\u00a0<\/em><strong>48<\/strong>, 580\u2013589 (2011)<\/li>\n<\/ol>\n<p>[\/vc_column_text][\/vc_column][vc_column width=&#8221;1\/2&#8243;][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row css=&#8221;.vc_custom_1702945561061{padding-top: 10vh !important;}&#8221;][vc_column width=&#8221;1\/6&#8243;][vc_column_text]Turnaround Time 21-25 business days[\/vc_column_text][\/vc_column][vc_column width=&#8221;1\/6&#8243;][vc_column_text]Price Inquire for pricing[\/vc_column_text][\/vc_column][vc_column width=&#8221;1\/6&#8243;][vc_column_text]Testing completed by Gene by Gene[\/vc_column_text][\/vc_column][vc_column width=&#8221;1\/6&#8243;][\/vc_column][vc_column width=&#8221;1\/6&#8243;][\/vc_column][vc_column width=&#8221;1\/6&#8243;][\/vc_column][\/vc_row][vc_row css=&#8221;.vc_custom_1702945023379{padding-top: 5vh !important;padding-bottom: 1vh !important;}&#8221;][vc_column width=&#8221;1\/2&#8243;][vc_tta_tabs active_section=&#8221;1&#8243;][vc_tta_section title=&#8221;Requirements&#8221; tab_id=&#8221;1702944281951-8a02fdf3-644c&#8221;][vc_column_text css_animation=&#8221;fadeIn&#8221; css=&#8221;.vc_custom_1709594135260{padding-top: 20px !important;padding-bottom: 20px !important;}&#8221;] | Sample Requirements myDNA will provide buccal (cheek) swab kits with each order. Each test requires one buccal [&hellip;]<\/p>\n","protected":false},"author":57,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"hero-banner.php","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-130278","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Whole Exome Sequencing can support better health outcomes | myDNA (United States)<\/title>\n<meta name=\"description\" content=\"WES uses Next Generation Sequencing methodology to provide targeted sequence information from the coding regions of the genome.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.mydna.life\/en-us\/whole-exome-sequencing\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Whole Exome Sequencing can support better health outcomes | myDNA (United States)\" \/>\n<meta property=\"og:description\" content=\"WES uses Next Generation Sequencing methodology to provide targeted sequence information from the coding regions of the genome.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.mydna.life\/en-us\/whole-exome-sequencing\/\" \/>\n<meta property=\"og:site_name\" content=\"myDNA (United States)\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/myDNAlife\/\" \/>\n<meta property=\"article:modified_time\" content=\"2025-01-16T23:05:58+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@myDNA_life\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.mydna.life\/en-us\/whole-exome-sequencing\/\",\"url\":\"https:\/\/www.mydna.life\/en-us\/whole-exome-sequencing\/\",\"name\":\"Whole Exome Sequencing can support better health outcomes | myDNA (United States)\",\"isPartOf\":{\"@id\":\"https:\/\/www.mydna.life\/en-us\/#website\"},\"datePublished\":\"2024-03-05T22:14:20+00:00\",\"dateModified\":\"2025-01-16T23:05:58+00:00\",\"description\":\"WES uses Next Generation Sequencing methodology to provide targeted sequence information from the coding regions of the genome.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.mydna.life\/en-us\/whole-exome-sequencing\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.mydna.life\/en-us\/whole-exome-sequencing\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.mydna.life\/en-us\/whole-exome-sequencing\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.mydna.life\/en-us\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Whole Exome Sequencing\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.mydna.life\/en-us\/#website\",\"url\":\"https:\/\/www.mydna.life\/en-us\/\",\"name\":\"myDNA (United States)\",\"description\":\"Go ahead. 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