Pharmacogenomic testing in Australia
More than 3,000 Australian GPs and specialists have already ordered over 12,000 myDNA pharmacogenomic tests to enable more informed, personalised prescribing for their patients.
Analysis of around 4,750 test results found that 70% of people have a finding that predicts a significantly altered drug metabolism for one or more medications.
Video: Associate Professor Les Sheffield, Clinical Geneticist, shares more about personalised medicine
About the myDNA test
The myDNA test is a pharmacogenomic test which identifies variations in a number of genes that affect medication response.
Currently, myDNA testing concentrates on the genes encoding the metabolising enzymes (i.e. CYP450 enzymes) which are found mainly in the liver as well as the gut wall. These genetic variations predict the level of enzyme activity which in turn results in increased or decreased plasma concentrations and drug exposure.
Increased plasma concentrations, due to reduced enzyme activity, can lead to adverse effects. Reduced plasma concentrations, due to increased enzyme activity, can lead to poor therapeutic response.
Enzyme function can also be affected by factors other than genotype, including age, the effect of co-administered drugs (i.e. drug-drug interactions), and the presence of liver disease. These should be taken into account when considering the myDNA test result.
Who is the myDNA test recommended for?
The patients likely to benefit from myDNA testing include those who are:
- Experiencing side effects to specific medications
- Not responding to specific medications
- Requiring doses of specific medications outside the recommended range
- Planning to start on a new medication covered by the myDNA test
- Taking multiple medications initiated by different prescribers
Each person who takes a myDNA test will receive a highly customised medication report and ongoing access to myDNA Explore – a secure online portal that provides information relevant to the person’s genetic profile.
How to order myDNA
Offering the myDNA test to your patients is simple and can be done using the following methods:
- Patients can be referred to a myDNA accredited pharmacy for a cheek swab test for $149. The sample is then sent to the lab for analysis and a personalised report is sent back to the requesting doctor and to the myDNA accredited pharmacist.
- A 4mL EDTA blood test can be ordered through our pathology partner Australian Clinical Labs for $169. Other pathology providers may add an additional charge for blood collection. The sample is then sent to the lab for analysis and a personalised report is sent back to the requesting doctor.
- Doctors may also wish to order the myDNA test kit online or direct to their clinic.