UGT1A1 Test Purpose
The UGT1A1 gene encodes the enzyme UDP-glucuronosyltransferase, crucial for bilirubin conjugation in the liver. Variants in this gene that result in reduced enzyme function may impact drug metabolism, potentially increasing susceptibility to adverse effects from medications such as irinotecan. UGT1A1 testing can assist with identifying individuals at a higher risk of toxicity, allowing the doctor to further personalise their treatment plan.
Reduced function alleles (e.g: UGT1A1*28) that are inherited in an autosomal recessive manner are a common cause of Gilbert’s syndrome. This condition is now understood to cause unconjugated hyperbilirubinemia, due to the presence of two UGT1A1 reduced function alleles.
myDNA’s NATA accredited laboratory performs pharmacogenomic testing to detect the following UGT1A1 variants:
*28 allele
*6 allele
How it works
We provide buccal test kits to your clinic at no charge, ready for sample collection.
Buccal kit includes a buccal swab, request form, instructions regarding sample collection, and an express prepaid return envelope
Step 1
Collect patient’s buccal sample during their consultation.
Step 2
Complete the request form and ask the patient to fill in their credit card details on the back.
Step 3
Place collected sample and completed request form inside the express prepaid return envelope and send back to our lab.
Step 4
Requesting the Test Kit:
Ordering
To order the UGT1A1 Test kit, please contact our customer service team:
P: 1300 463 373
Sample Required:
Buccal
(Results from a buccal swab sample are equally reliable to results from a blood sample)
Turnaround Time:
DPYD results are available within 3 days on sample receipt.
Price:
UGT1A1 Test is priced at $160.
DPYD/UGT1A1 Combined Test is priced at $250.
Please note that this test is not eligible for Medicare rebates.
Clinical Team
The myDNA clinical team consists of qualified clinical geneticists, pharmacists and pharmacologists with expertise in the clinical application of pharmacogenomics.
The team is available to discuss results. Simply call us on 1300 436 373.
Downloadable Resources
UGT1A1 Brochure
UGT1A1 Request Form
Enquire Here
For further information please provide your details and we will respond within 2 business days.
Patient Privacy and Security
All DNA remains the property of the patient. DNA samples are de-identified upon arrival at our laboratory to ensure all DNA remains anonymous, and our DNA analysis technique cannot be used to identify individuals or their relatives. myDNA will never share any patient data with third parties without written consent and uses secure encrypted servers to protect it.