Chronic inflammation, while a key defense mechanism of the body, can become a hidden driver of diseases such as obesity, diabetes, heart disease, and cancer when it persists unchecked. DNA testing offers an opportunity to uncover genetic predispositions that contribute to inflammation and help craft personalized, effective strategies for your patients.
This guide focuses on three key areas: the pathways of inflammation, the main SNPs involved, and practical applications for managing inflammation.
Chronic inflammation, while a key defense mechanism of the body, can become a hidden driver of diseases such as obesity, diabetes, heart disease, and cancer when it persists unchecked. DNA testing offers an opportunity to uncover genetic predispositions that contribute to inflammation and help craft personalized, effective strategies for your patients.
This guide focuses on three key areas: the pathways of inflammation, the main SNPs involved, and practical applications for managing inflammation.
Pathways of Inflammation
- Oxidative Stress
Oxidative stress occurs when there’s an imbalance between free radicals and antioxidants. Variants in genes like GSTM1, GPX1, and NOS1 can affect the body’s ability to neutralize oxidative damage, increasing the risk of inflammation.
- Cytokine Regulation
Pro-inflammatory cytokines such as TNF-α and IL6 play central roles in chronic inflammation. Genetic variants in these pathways can lead to heightened inflammatory responses, contributing to disease risk.
- Inflammation Resolution
Omega-3 fatty acids (EPA and DHA) are essential for resolving inflammation. Variants in genes like FADS1 and FADS2 may reduce the conversion efficiency of plant-based omega-3s to active forms, impacting resolution processes.
Main SNPs and Practical Applications
- Addressing Oxidative Stress
GSTM1, GPX1: Recommend a diet rich in antioxidants (e.g., berries, green tea, cruciferous vegetables) and supplements such as selenium and curcumin to support glutathione activity.
NOS1: Encourage omega-3 fatty acids and carotenoids to mitigate oxidative damage.
- Balancing Cytokine Activity
TNF-α, IL6: Anti-inflammatory diets with omega-3s, polyphenols, and curcumin can help modulate cytokine production.
PEMT: Suggest choline-rich foods like eggs and soy to improve cellular function and manage inflammation.
- Supporting Inflammation Resolution
FADS1, FADS2: Ensure adequate intake of direct omega-3 sources like fatty fish or EPA/DHA supplements for patients with reduced conversion capacity.
Takeaway
Understanding the genetic drivers of chronic inflammation allows practitioners to personalize interventions that address the root cause of their patients’ issues. A genetic panel focused on inflammation, coupled with actionable recommendations, can help reduce inflammation and improve long-term health outcomes.
Starting with a simple DNA test can unlock critical insights to help your patients achieve better health and vitality.
